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COLLECTIVE CELL MIGRATION

Steering from the rear

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In the absence of biochemical gradients, cancer cell migration over fibrillar isotropic collagen can occur by a mechanical self-steering process involving asymmetric matrix deformation from the rear.

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Fig. 1: Asymmetry of structural and molecular signals involved in collective migration on viscoelastic collagen networks.

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Authors and Affiliations

  1. Department of Cell Biology, Radboud University Medical Centre, Nijmegen, The Netherlands

    Katarina Wolf & Peter Friedl

  2. David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Peter Friedl

  3. Cancer Genomics Center, Utrecht, The Netherlands

    Peter Friedl

Authors
  1. Katarina Wolf
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  2. Peter Friedl
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Correspondence to Katarina Wolf or Peter Friedl.

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The authors declare no competing interests.

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Wolf, K., Friedl, P. Steering from the rear. Nat. Mater. 21, 1104–1105 (2022). https://doi.org/10.1038/s41563-022-01357-4

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