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Active transcytosis and new opportunities for cancer nanomedicine

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New evidence suggests that the mechanism of nanoparticle entry into solid tumours may be driven by an active process. This insight paves the way for approaches to enhance the efficiency of nanomedicine delivery by harnessing active transport mechanisms, and encourage researchers to rethink how tumours are treated.

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Fig. 1: Active and passive mechanisms for in vivo nanoparticle delivery.

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Authors and Affiliations

  1. Department of Chemistry, University of Illinois at Urbana–Champaign, Urbana, IL, USA

    Subehndu Pandit & Shuming Nie

  2. Department of Bioengineering, University of Illinois at Urbana–Champaign, Urbana, IL, USA

    Debapriya Dutta & Shuming Nie

Authors
  1. Subehndu Pandit
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  2. Debapriya Dutta
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  3. Shuming Nie
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Correspondence to Shuming Nie.

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Pandit, S., Dutta, D. & Nie, S. Active transcytosis and new opportunities for cancer nanomedicine. Nat. Mater. 19, 478–480 (2020). https://doi.org/10.1038/s41563-020-0672-1

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