A dose threshold of one trillion nanoparticles in mice has been discovered and is shown to be crucial for overwhelming the nanoparticle uptake kinetics of liver Kupffer cells and for ensuring efficient nanoparticle delivery into solid tumours upon intravenous administration.
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Lammers, T. Just dose it. Nat. Mater. 19, 1257–1258 (2020). https://doi.org/10.1038/s41563-020-00855-7
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DOI: https://doi.org/10.1038/s41563-020-00855-7
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