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IMPLANT DEBRIS

Induction of sterile type 2 inflammation

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Microparticle debris from prosthetic implants has been shown to induce a type 2 inflammatory response through a Bruton’s tyrosine kinase-dependent signalling pathway.

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Fig. 1: A schematic of the type 2 inflammatory response to wear debris associated with implants.

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Authors and Affiliations

  1. Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA

    Dimitri A. de Kouchkovsky & Carla V. Rothlin

  2. Department of Pharmacology, Yale University, New Haven, CT, USA

    Sourav Ghosh & Carla V. Rothlin

  3. Department of Neurology, Yale University, New Haven, CT, USA

    Sourav Ghosh

Authors
  1. Dimitri A. de Kouchkovsky
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  2. Sourav Ghosh
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  3. Carla V. Rothlin
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Corresponding authors

Correspondence to Sourav Ghosh or Carla V. Rothlin.

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de Kouchkovsky, D.A., Ghosh, S. & Rothlin, C.V. Induction of sterile type 2 inflammation. Nature Mater 18, 193–194 (2019). https://doi.org/10.1038/s41563-019-0300-0

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