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PROTEIN EVOLUTION

Characterizing the landscape of evolvability

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A framework to experimentally traverse the large space of functionally neutral variants in a toxin–antitoxin protein complex reveals insights on evolvability and entrenchment of molecular interactions.

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Fig. 1: Mutational analysis of toxin–antitoxin binding.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Texas at Dallas, Richardson, TX, USA

    Faruck Morcos

  2. Center for Systems Biology, University of Texas at Dallas, Richardson, TX, USA

    Faruck Morcos

  3. Department of Bioengineering, University of Texas at Dallas, Richardson, TX, USA

    Faruck Morcos

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  1. Faruck Morcos
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Correspondence to Faruck Morcos.

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Morcos, F. Characterizing the landscape of evolvability. Nat Ecol Evol 6, 500–501 (2022). https://doi.org/10.1038/s41559-022-01731-0

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