The immune system must distinguish self from non-self, but an imbalanced reaction in either direction can lead to immunopathology or severe infection. A new model incorporating host life history predicts which error will be more tolerated.
This is a preview of subscription content, log in via an institution to check access.
References
Metcalf, C. J. E., Tate, A. T. & Graham, A. L. Nat. Ecol. Evol. https://doi.org/10.1038/s41559-017-0315-3 (2017).
Wardemann, H. et al. Science 301, 1374–1377 (2003).
Scalapino, K. J. & Daikh, D. I. Immunol. Rev. 223, 143–155 (2008).
Duffy, L. & O’Reilly, S. C. ImmunoTargets Ther. 5, 69–80 (2016).
Boots, M. et al. Parasite Immunol. 35, 331–338 (2013).
Mayer, A. et al. Proc. Natl Acad. Sci. USA 113, 8630–8635 (2016).
Simon, A. K. et al. Proc. R. Soc. B 282, 20143085 (2015).
Brodin, P. & Davis, M. M. Nat. Rev. Immunol. 17, 21–29 (2017).
Gruver, A. L. et al. J. Pathol. 211, 144–156 (2007).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Cobey, S. Sick if you do, sick if you don’t. Nat Ecol Evol 1, 1602–1603 (2017). https://doi.org/10.1038/s41559-017-0342-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41559-017-0342-0
- Springer Nature Limited