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Synthetic methodology

Sulfur stereochemistry takes centre stage

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Directional interactions and three-dimensional functional groups are crucial to medicinal compounds. Consequently, new functional groups require stereocontrolled synthetic methods. Now, an enantiopure building block provides controlled and divergent access to valuable sulfonimidoyl functional groups.

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Fig. 1: Development of an enantiopure bifunctional aza-sulfur(VI) reagent for the asymmetric synthesis of sulfonimidoyl fluorides, sulfoximines and sulfonimidamides.

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Correspondence to James A. Bull.

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Bull, J.A. Sulfur stereochemistry takes centre stage. Nat. Chem. 16, 152–153 (2024). https://doi.org/10.1038/s41557-023-01421-9

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