As the need for specific fluorescent probes that enable high sensitivity and super-resolution imaging experiments continues to grow, it is imperative to develop new, well-characterized methods to modulate the emission of fluorophores. Now, a general platform affords visible-to-NIR fluorogenic fluorophores by engineering a simple cyclization event into cyanine dyes.
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Wilson, Q.D., Sletten, E.M. Engineering cyanine cyclizations for new fluorogenic probes. Nat. Chem. 16, 3–5 (2024). https://doi.org/10.1038/s41557-023-01408-6
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DOI: https://doi.org/10.1038/s41557-023-01408-6
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