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Synthetic methodology

Boron-enabled 1,3-metallate shift towards axially chiral alkenes

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Tetracoordinate boron molecules are the key intermediates in many organoboron-related chemical transformations. Now, using alkynyl tetracoordinate boron species, a nickel-catalysed asymmetric 1,3-metallate shift towards axial chirality has been developed, giving access to various axially chiral alkenes in high efficiency.

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Fig. 1: Asymmetric synthesis based on the metallate shift of tetracoordinate borons.

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Authors and Affiliations

  1. Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen, China

    Li-Qing Ren & Chuan He

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  1. Li-Qing Ren
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  2. Chuan He
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Correspondence to Chuan He.

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The authors declare no competing interests.

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Ren, LQ., He, C. Boron-enabled 1,3-metallate shift towards axially chiral alkenes. Nat. Chem. 16, 8–9 (2024). https://doi.org/10.1038/s41557-023-01399-4

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