Pharmacologically inactive prodrugs that can be activated by near-infrared light are attractive candidates for clinical applications. Now, platinum-based photo-oxidants have been shown to eradicate tumours in mice with a new mode of action.
This is a preview of subscription content, log in via an institution to check access.
References
Bevernaegie, R. et al. J. Am. Chem. Soc. 142, 2732–2737 (2020).
Cuello-Garibo, J.-A., Meijer, M. S. & Bonnet, S. Chem. Commun. 53, 6768–6771 (2017).
Steinke, S. J. et al. Chem. Sci. 13, 1933–1945 (2022).
McFarland, S. A., Mandel, A., Dumoulin-White, R. & Gasser, G. Curr. Opin. Chem. Biol. 56, 23–27 (2020).
Deng, Z. et al. Nat. Chem. https://doi.org/10.1038/s41557-023-01242-w (2023).
Johnstone, T. C., Suntharalingam, K. & Lippard, S. J. Chem. Rev. 116, 3436–3486 (2016).
Bolitho, E. M. et al. J. Am. Chem. Soc. 143, 20224–20240 (2021).
Roque, J. A. et al. Chem. Sci. 11, 9784–9806 (2020).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Vigueras, G., Gasser, G. Anticancer platinum-based photo-oxidants in a new light. Nat. Chem. 15, 896–898 (2023). https://doi.org/10.1038/s41557-023-01250-w
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41557-023-01250-w
- Springer Nature Limited