Malleicyprols are highly reactive polyketides responsible for virulence in some pathogenic bacteria. Now, the enzyme that constructs the cyclopropanol warhead of malleicyprols has been identified. This enzyme could represent a useful target for developing new antivirulence therapeutics.
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Abraham, E., Butcher, R.A. Warhead assembly in a lethal pathogen. Nat. Chem. 14, 848–850 (2022). https://doi.org/10.1038/s41557-022-01013-z
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DOI: https://doi.org/10.1038/s41557-022-01013-z
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