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SYNTHETIC METHODOLOGY

Tungsten’s tandem transformation

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Being able to run two reactions concurrently enables synthetic methods to be streamlined, but simultaneously controlling the selectivity of both reactions is an enormous challenge. Now, a directing group is used to reinvent a classic tandem reaction, activating specific sp3 C–H bonds with pinpoint accuracy.

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Fig. 1: Overview of isomerization/carbonylation tandem catalysis.

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Authors and Affiliations

  1. Department of Chemistry, Temple University, Philadelphia, PA, USA

    Sarah E. Jenny & Graham E. Dobereiner

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  1. Sarah E. Jenny
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  2. Graham E. Dobereiner
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Correspondence to Graham E. Dobereiner.

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The authors declare no competing interests.

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Jenny, S.E., Dobereiner, G.E. Tungsten’s tandem transformation. Nat. Chem. 14, 594–595 (2022). https://doi.org/10.1038/s41557-022-00953-w

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