Skip to main content
SpringerLink
Log in

NUCLEIC ACIDS

Designing in vivo active DNAzymes

  • News & Views
  • Published:

From Nature Chemistry

View current issue Submit your manuscript

The therapeutic applications of DNAzymes are limited because of their low effectiveness in vivo. Now, a promising approach for constructing DNAzymes that show high gene-silencing efficiency in mammalian cells has been developed. This approach incorporates chemical modifications into an existing DNAzyme scaffold.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Design of DNAzymes for efficient gene silencing in vivo.

References

  1. Roberts, T. C., Langer, R. & Wood, M. J. A. Nat. Rev. Drug Discov. 19, 673–694 (2020).

    Article  CAS  Google Scholar 

  2. Silverman, S. K. Trends Biochem. Sci. 41, 595–609 (2016).

    Article  CAS  Google Scholar 

  3. Wang, Y., Nguyen, K., Spitale, R. C. & Chaput, J. C. Nat. Chem. https://doi.org/10.1038/s41557-021-00645-x (2021).

    Article  PubMed  Google Scholar 

  4. Breaker, R. R. & Joyce, G. F. Cell Chem. Biol. 1, 223–229 (1994).

    CAS  Google Scholar 

  5. Santoro, S. W. & Joyce, G. F. Proc. Natl Acad. Sci. USA 94, 4262–4266 (1997).

    Article  CAS  Google Scholar 

  6. Hollenstein, M. Curr. Opin. Chem. Biol. 52, 93–101 (2019).

    Article  CAS  Google Scholar 

  7. Schubert, S. et al. Nucleic Acids Res. 31, 5982–5992 (2003).

    Article  CAS  Google Scholar 

  8. Fokina, A. A., Meschaninova, M. I., Durfort, T., Venyaminova, A. G. & François, J.-C. Biochemistry 51, 2181–2191 (2012).

    Article  CAS  Google Scholar 

  9. Damha, M. J. et al. J. Am. Chem. Soc. 120, 12976–12977 (1998).

    Article  CAS  Google Scholar 

  10. Chaput, J. C. Acc. Chem. Res. 54, 1056–1065 (2021).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, Nankai University, Tianjin, China

    Yifei Zhou & Chuanzheng Zhou

Authors
  1. Yifei Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chuanzheng Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chuanzheng Zhou.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhou, Y., Zhou, C. Designing in vivo active DNAzymes. Nat. Chem. 13, 299–301 (2021). https://doi.org/10.1038/s41557-021-00669-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41557-021-00669-3

  • Springer Nature Limited

This article is cited by

Search

Navigation