Metal-catalysed hydroformylations efficiently convert feedstock alkenes into aldehydes, though typically relatively simple ones. Now, the palladium-catalysed fragmentation of acid chlorides followed by reassembly with alkynes and silanes has been shown to form valuable, highly substituted α,β-unsaturated aldehydes.
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References
Beller, M. & Wu, X.-F. Transition Metal Catalyzed Carbonylation Reactions (Springer, 2013).
Börner, A. & Franke, R. Hydroformylation: Fundamentals, Processes, and Applications in Organic Synthesis (Wiley-VCH, 2016).
Lee, Y. H., Denton, E. H. & Morandi, B. Nat. Chem. https://doi.org/10.1038/s41557-020-00621-x (2021).
Fang, X., Cacherat, B. & Morandi, B. Nat. Chem. 9, 1105–1109 (2017).
Lee, Y. H. & Morandi, B. Nat. Chem. 10, 1016–1022 (2018).
De La Higuera Macias, M. & Arndtsen, B. A. J. Am. Chem. Soc. 140, 10140–10144 (2018).
Brown, S., Clarkson, S., Grigg, R. & Sridharan, V. J. Chem. Soc., Chem. Commun. 1135–1136 (1995).
Zhang, S., Neumann, H. & Beller, M. Chem. Soc. Rev. 49, 3187–3210 (2020).
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Zgheib, J., Arndtsen, B.A. Fragmentation and reassembly. Nat. Chem. 13, 110–111 (2021). https://doi.org/10.1038/s41557-020-00631-9
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DOI: https://doi.org/10.1038/s41557-020-00631-9
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