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NATURAL PRODUCT SYNTHESIS

Simple start for complex products

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Natural products often provide lead scaffolds for the development of therapeutics, but complexity of their synthesis can limit the discovery of improved analogues. Pharmacophore-directed retrosynthesis aims to accelerate the building of a structure–activity relationship profile of a natural product, aiming to identifying a simplified lead.

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Fig. 1: Pharmacophore-directed retrosynthesis (PDR).

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Authors and Affiliations

  1. Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, 12415 Medical Research Building IV, Nashville, TN, USA

    Jason R. Hudlicky & Gary A. Sulikowski

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  1. Jason R. Hudlicky
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  2. Gary A. Sulikowski
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Correspondence to Gary A. Sulikowski.

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Hudlicky, J.R., Sulikowski, G.A. Simple start for complex products. Nat. Chem. 11, 297–298 (2019). https://doi.org/10.1038/s41557-019-0241-x

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