The structure of an antibiotic that is effective against Gram-positive bacteria, but not against Gram-negative bacteria, has now been modified to improve its effectiveness against Gram-negative bacteria. The approach could help broaden the spectrum of activity of other antibiotics.
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References
Bonomo, R. A. et al. Clin. Infect. Dis. 66, 1290–1297 (2018).
Sherry, N. & Howden, B. Expert Rev. Anti-Infect. Ther. 16, 289–306 (2018).
Smith, P. A. et al. Nature https://doi.org/10.1038/s41586-018-0483-6 (2018).
Collinson, I., Corey, R. A. & Allen, W. J. Philos. Trans. R. Soc. London Ser. B 370, 20150025 (2015).
Tsirigotaki, A., De Geyter, J., Šoštaric, N., Economou, A. & Karamanou, S. Nat. Rev. Microbiol. 15, 21–36 (2017).
Auclair, S. M., Bhanu, M. K. & Kendall, D. A. Protein Sci. 21, 13–25 (2012).
Walsh, S. I., Craney, A. & Romesberg, F. E. Bioorg. Med. Chem. 24, 6370–6378 (2016).
Liu, J., Smith, P. A., Steed, D. B. & Romesberg, F. Bioorg. Med. Chem. Lett. 23, 5654–5659 (2013).
Silver, L. L. Bioorg. Med. Chem. 24, 6379–6389 (2016).
Richter, M. F. et al. Nature 545, 299–304 (2017).
Tommasi, R., Iyer, R. & Miller, A. A. ACS Infect. Dis. 4, 686–695 (2018).
Richter, M. F. & Hergenrother, P. J. Ann. N. Y. Acad. Sci. https://doi.org/10.1111/nyas.13598 (2018).
Peters, D. S., Romesberg, F. E. & Baran, P. S. J. Am. Chem. Soc. 140, 2072–2075 (2018).
Yeh, C.-H. et al. ACS Med. Chem. Lett. 9, 376–380 (2018).
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Fisher, J.F., Mobashery, S. A positive positive to negative. Nature Chem 10, 998–1000 (2018). https://doi.org/10.1038/s41557-018-0148-y
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DOI: https://doi.org/10.1038/s41557-018-0148-y
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