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DYNAMIC COVALENT CHEMISTRY

SNAr stands corrected

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Dynamic covalent chemistry combines the error-correcting behaviour of supramolecular chemistry with the robustness of covalent bonding, but relies on a somewhat limited set of reactions. Now, the classic nucleophilic aromatic substitution (SNAr) reaction has been shown to be reversible and self-correcting.

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Fig. 1: Dynamic, self-correcting SNAr reaction.
Fig. 2: Macrocycle and polymer synthesized through SNAr.

References

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Authors and Affiliations

  1. The Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO, USA

    Yinghua Jin & Wei Zhang

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  1. Yinghua Jin
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  2. Wei Zhang
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Correspondence to Wei Zhang.

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Jin, Y., Zhang, W. SNAr stands corrected. Nature Chem 10, 996–998 (2018). https://doi.org/10.1038/s41557-018-0138-0

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