When transcription by RNA polymerase II is stalled by ultraviolet-induced DNA damage, it recruits repair factors, leading to excision of the damaged site and DNA synthesis to fill the gap. Three new studies show that, for aldehyde-induced DNA crosslinks, repair is activated by the same factors, but without base excision and gap filling.
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References
Berti, M., Cortez, D. & Lopes, M. Nat. Rev. Mol. Cell Biol. 21, 633–651 (2020).
Sanz-Murillo, M. et al. Proc. Natl Acad. Sci. USA 115, 8972–8977 (2018).
Xu, J. et al. Nature 551, 653–657 (2017).
Lans, H., Hoeijmakers, J. H. J., Vermeulen, W. & Marteijn, J. A. Nat. Rev. Mol. Cell Biol. 20, 766–784 (2019).
Nieto Moreno, N., Olthof, A. M. & Svejstrup, J. Q. Annu. Rev. Biochem. 92, 81–113 (2023).
Mulderrig, L. et al. Nature 600, 158–163 (2021).
van Sluis, M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01394-y (2024).
Oka, Y., Nakazawa, Y., Shimada, M. & Ogi, T. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01401-2 (2024).
Carnie, C. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01391-1 (2024).
Kokic, G. et al. Nat. Struct. Mol. Biol. 31, 536–547 (2024).
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Saponaro, M. Adding a transcription-coupled repair pathway. Nat Cell Biol (2024). https://doi.org/10.1038/s41556-024-01399-7
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DOI: https://doi.org/10.1038/s41556-024-01399-7
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