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WIPI4 loss linked to ferroptosis

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β-propeller protein-associated neurodegeneration (BPAN) is caused by loss of functional WIPI4. A new study reports that depletion of WIPI4 induces ferroptosis via changes in mitochondrial membrane lipids, independently of the role of WIPI4 in autophagy, providing insights into the cause of neurodegeneration in BPAN.

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Fig. 1: WIPI4 depletion causes changes in mitochondrial membrane lipids and induces ferroptosis.

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Authors and Affiliations

  1. Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA

    Yang Liu & Hongyuan Yang

  2. Molecular and Translational Biology Program, The University of Texas MD Anderson Cancer Center, UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA

    Yang Liu

  3. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia

    Hongyuan Yang

Authors
  1. Yang Liu
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  2. Hongyuan Yang
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Correspondence to Yang Liu or Hongyuan Yang.

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The authors declare no competing interests.

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Liu, Y., Yang, H. WIPI4 loss linked to ferroptosis. Nat Cell Biol 26, 506–507 (2024). https://doi.org/10.1038/s41556-024-01359-1

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