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Order and disorder in clathrin-mediated endocytosis

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The generation of clathrin-coated vesicles during endocytosis requires the co-ordinated recruitment of dozens of proteins to the plasma membrane. We discovered that the plant TPLATE (or TSET) complex (TPC) undergoes biomolecular condensation through interactions with plasma membrane phospholipids and, via weak multivalent interactions, recruits clathrin and other endocytic proteins to facilitate the efficient progression of endocytosis.

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Fig. 1: Condensation of AtEH1 facilitates clathrin assembly.

References

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This is a summary of: Dragwidge, J. M. et al. Biomolecular condensation orchestrates clathrin-mediated endocytosis in plants. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01354-6 (2024).

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Order and disorder in clathrin-mediated endocytosis. Nat Cell Biol 26, 327–328 (2024). https://doi.org/10.1038/s41556-024-01355-5

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