Activation of innate immunity has been linked to the progression of type 1 diabetes. A study now shows that overexpression of METTL3, a writer protein of the m6A machinery that modifies mRNA, restrains interferon-stimulated genes when expressed in pancreatic β-cells, identifying it as a promising therapeutic target.
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References
Insel, R. A. et al. Diabetes Care 38, 1964–1974 (2015).
Cantley, J., Eizirik, D. L., Latres, E. & Dayan, C. M. J. Endocrinol. 259, e230082 (2023).
De George, D. J., Ge, T., Krishnamurthy, B., Kay, T. W. H. & Thomas, H. E. Front. Cell Dev. Biol. 11, 1205590 (2023).
De Jesus, D. F. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01368-0 (2024).
Han, D. & Xu, M. M. Annu. Rev. Immunol. 41, 73–98 (2023).
Winkler, R. et al. Nat. Immunol. 20, 173–182 (2019).
Hornung, V., Hartmann, R., Ablasser, A. & Hopfner, K. P. Nat Rev Immunol 14, 521–528 (2014).
Sims, E. K., Mirmira, R. G. & Evans-Molina, C. Curr. Opin. Endocrinol. Diabetes Obes. 27, 215–224 (2020).
Jhala, G. et al. Cell Rep 39, 110747 (2022).
Li, H. B. et al. Nature 548, 338–342 (2017).
Huang, H. et al. Nat. Cell Biol. 20, 285–295 (2018).
Flodstrom, M. et al. Nat. Immunol. 4, 4 (2002).
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Krishnamurthy, B., Thomas, H.E. METTL3 restrains autoimmunity in β-cells. Nat Cell Biol 26, 321–322 (2024). https://doi.org/10.1038/s41556-024-01352-8
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DOI: https://doi.org/10.1038/s41556-024-01352-8
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