Skip to main content

Advertisement

SpringerLink
Log in

Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1

  • Research Briefing
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

The chemoresistant and immunoevasive characteristics of leukaemia stem cells (LSCs) impede the treatment efficacy for acute myeloid leukaemia (AML). We find that inhibiting the tyrosine phosphatase SHP-1 effectively alters the metabolic state of LSCs, making them more susceptible to chemotherapy and immune surveillance in AML.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: SHP-1 inhibition enhances the efficacy of chemotherapy and immune surveillance in AML.

References

  1. Hope, K. J., Jin, L. & Dick, J. E. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat. Immunol. 5, 738–743 (2004). This paper reports the heterogeneity of LSCs.

    Article  CAS  PubMed  Google Scholar 

  2. Jones, C. L., Inguva, A. & Jordan, C. T. Targeting energy metabolism in cancer stem cells: progress and challenges in leukemia and solid tumors. Cell Stem Cell 28, 378–393 (2021). A review article that summarises the metabolic properties of cancer stem cells.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Jiang, L. et al. SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-beta signaling. J. Exp. Med. 215, 1337–1347 (2018). This paper reports the role of SHP-1 in haematopoietic stem cells.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Vainonen, J. P., Momeny, M. & Westermarck, J. Druggable cancer phosphatases. Sci. Transl. Med. 13, eabe2967 (2021). A review article that presents the pharmacological approaches for targeting phosphatases in cancer treatment.

    Article  CAS  PubMed  Google Scholar 

  5. Li, L. & Clevers, H. Coexistence of quiescent and active adult stem cells in mammals. Science 327, 542–545 (2010). A review article that presents the heterogeneity of adult stem cells.

    Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Xu, X. et al. SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming. Nat. Cell Biol. https://doi.org/10.1038/s41556-024-01349-3 (2024).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Metabolic regulation of chemoresistance and immuno-surveillance in AML by SHP-1. Nat Cell Biol 26, 329–330 (2024). https://doi.org/10.1038/s41556-024-01350-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-024-01350-w

  • Springer Nature Limited

Search

Navigation