The tumour microenvironment produces nutrients that propel cancer development. New work finds that pancreatic ductal adenocarcinoma cells use one such nutrient, acetate, to alter protein acetylation, rerouting polyamine metabolism and promoting cell growth under acidosis—a finding with potential implications for treating this cancer.
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Yin, M., Lei, QY. Targeting stromal metabolism in pancreatic ductal adenocarcinoma. Nat Cell Biol 26, 514–515 (2024). https://doi.org/10.1038/s41556-023-01330-6
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DOI: https://doi.org/10.1038/s41556-023-01330-6
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