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Cell origin of BRCA2-mutant breast cancer

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The different compartments of the mammary stem cell hierarchy develop into distinct breast cancer subtypes as a result of specific genetic lesions. A recent study identifies aberrant ERBB3low luminal progenitors with altered proteostasis and translation as the cell of origin of BRCA2-mutant breast cancer.

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Fig. 1: A normal mammary cell hierarchy may develop into distinct breast tumour subtypes.

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Authors and Affiliations

  1. Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Cancer Institutes, State Key Laboratory of Genetic Engineering, Key Laboratory of Breast Cancer in Shanghai, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

    Jiahui Xu & Suling Liu

  2. The Shanghai Key Laboratory of Medical Epigenetics, Shanghai, China

    Suling Liu

  3. Shanghai Key Laboratory of Radiation Oncology, Shanghai, China

    Suling Liu

Authors
  1. Jiahui Xu
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  2. Suling Liu
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Correspondence to Suling Liu.

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The authors declare no competing interests.

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Xu, J., Liu, S. Cell origin of BRCA2-mutant breast cancer. Nat Cell Biol 26, 43–44 (2024). https://doi.org/10.1038/s41556-023-01322-6

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