Lineage transitions are a central feature of prostate development, tumorigenesis and treatment resistance. We discovered that inhibition of mitochondrial pyruvate uptake results in large-scale chromatin remodelling of key lineage-specific genes, antagonizes luminal lineage identity, and alters response to antiandrogen therapy in prostate cancer.
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This is a summary of: Giafaglione, J. M. et al. Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01274-x (2023).
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Pyruvate metabolism regulates prostate cell fate and response to cancer therapy. Nat Cell Biol 25, 1734–1735 (2023). https://doi.org/10.1038/s41556-023-01290-x
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DOI: https://doi.org/10.1038/s41556-023-01290-x
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