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Cytosolic transfer of circulating LPS by EVs

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The main barriers for intracellular receptors to sense circulating pathogen-associated molecular patterns (PAMPs) is how these PAMPs enter the cells. A study reveals that extracellular vesicles (EVs) bind lipopolysaccharide (LPS) via the lipid bilayer and mediates LPS intracellular transfer in a CD14-dependent endocytosis to activate noncanonical NLRP3 inflammasome and pyroptosis.

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Fig. 1: EV-mediated intracellular transfer of LPS induces noncanonical inflammasome activation.

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Authors and Affiliations

  1. Insitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China

    Yi Huang & Rongbin Zhou

  2. The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China

    Rongbin Zhou

Authors
  1. Yi Huang
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  2. Rongbin Zhou
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Correspondence to Rongbin Zhou.

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Huang, Y., Zhou, R. Cytosolic transfer of circulating LPS by EVs. Nat Cell Biol 25, 1729–1731 (2023). https://doi.org/10.1038/s41556-023-01283-w

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