Skip to main content
SpringerLink
Log in

Historical News & Views: Mechanobiology

Talking with force at cell–cell adhesions

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Cell–cell adhesions are inevitably exposed to mechanical forces. A landmark paper by Yonemura et al. identified how tension alters molecular function of the cadherin adhesion apparatus. Its legacy lies in the many on-going efforts to understand how mechanical force is used in cell–cell communication.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Mechanotransduction at adherens junctions.

References

  1. Gumbiner, B. M. Nat. Rev. Mol. Cell Biol. 6, 622–634 (2005).

    Article  CAS  PubMed  Google Scholar 

  2. Yonemura, S., Wada, Y., Watanabe, T., Nagafuchi, A. & Shibata, M. Nat. Cell Biol. 12, 533–542 (2010).

    Article  CAS  PubMed  Google Scholar 

  3. Ladoux, B. et al. Biophys. J. 98, 534–542 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. le Duc, Q. et al. J. Cell Biol. 189, 1107–1115 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Rangarajan, E. S. & Izard, T. J. Biol. Chem. 287, 18492–18499 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Yao, M. et al. Nat. Commun. 5, 4525 (2014).

    Article  CAS  PubMed  Google Scholar 

  7. Manibog, K., Li, H., Rakshit, S. & Sivasankar, S. Nat. Commun. 5, 3941 (2014).

    Article  CAS  PubMed  Google Scholar 

  8. Buckley, C. D. et al. Science 346, 1254211 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Noordstra, I. et al. Dev. Cell 58, 1748–1763 (2023).

    Article  CAS  PubMed  Google Scholar 

  10. Guillot, C. & Lecuit, T. Science 340, 1185–1189 (2013).

    Article  CAS  PubMed  Google Scholar 

  11. Villars, A. & Levayer, R. Curr. Opin. Genet. Dev. 72, 8–14 (2022).

    Article  CAS  PubMed  Google Scholar 

  12. Salvi, A. M. & DeMali, K. A. Curr. Opin. Cell Biol. 54, 114–120 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Howard, J., Grill, S. W. & Bois, J. S. Nat. Rev. Mol. Cell Biol. 12, 392–398 (2011).

    Article  PubMed  Google Scholar 

  14. Martin, A. C., Kaschube, M. & Wieschaus, E. F. Nature 457, 495–499 (2009).

    Article  CAS  PubMed  Google Scholar 

  15. Eisenhoffer, G. T. & Rosenblatt, J. Trends Cell Biol. 23, 185–192 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland, Australia

    Zoya Mann & Alpha S. Yap

Authors
  1. Zoya Mann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alpha S. Yap
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alpha S. Yap.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mann, Z., Yap, A.S. Talking with force at cell–cell adhesions. Nat Cell Biol 26, 26–28 (2024). https://doi.org/10.1038/s41556-023-01263-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-023-01263-0

  • Springer Nature Limited

Search

Navigation