Mitochondria can shuttle between adjacent cells or travel to distant organs by breaking away from the parent cell and entering the circulation. Here, we briefly review the state of research into mitochondria transfer, and discuss a methodological framework for studying the process.
This is a preview of subscription content, log in via an institution to check access.
References
Rustom, A., Saffrich, R., Markovic, I., Walther, P. & Gerdes, H. H. Science 303, 1007–1010 (2004).
Spees, J. L., Olson, S. D., Whitney, M. J. & Prockop, D. J. Proc. Natl Acad. Sci. USA 103, 1283–1288 (2006).
Liu, Z., Sun, Y., Qi, Z., Cao, L. & Ding, S. Cell Biosci. 12, 66 (2022).
Crewe, C. et al. Cell Metab. 33, 1853–1868.e1811 (2021).
Soubannier, V. et al. Curr. Biol. 22, 135–141 (2012).
Rosina, M. et al. Cell Metab. 34, 533–548.e512 (2022).
Todkar, K. et al. Nat. Commun. 12, 1971 (2021).
D’Acunzo, P. et al. Sci. Adv. 7, eabe5085 (2021).
Borcherding, N. & Brestoff, J. R. Nature https://doi.org/10.1038/s41586-023-06537-z (2023).
Konari, N., Nagaishi, K., Kikuchi, S. & Fujimiya, M. Sci. Rep. 9, 5184 (2019).
Yao, Y. et al. Stem Cell Rep. 11, 1120–1135 (2018).
Hayakawa, K. et al. Nature 535, 551–555 (2016).
Borcherding, N. et al. Cell Metab. 34, 1499–1513.e1498 (2022).
Nicolas-Avila, J. A. et al. Cell 183, 94–109.e123 (2020).
Brestoff, J. R. et al. Cell Metab. 33, 270–282.e278 (2021).
Zhao, Z., Wijerathne, H., Godwin, A. K. & Soper, S. A. Extracell. Vesicles Circ. Nucl. Acids 2, 80–103 (2021).
Jiang, L. et al. Sci. Rep. 7, 14444 (2017).
Perry, S. W., Norman, J. P., Barbieri, J., Brown, E. B. & Gelbard, H. A. Biotechniques 50, 98–115 (2011).
Mistry, J. J. et al. Proc. Natl Acad. Sci. USA 116, 24610–24619 (2019).
Saha, T. et al. Nat. Nanotechnol. 17, 98–106 (2022).
Marlein, C. R. et al. Blood 130, 1649–1660 (2017).
Song, A. J. & Palmiter, R. D. Trends Genet. 34, 333–340 (2018).
Liang, W. et al. Nat. Commun. 14, 5031 (2023).
Bukoreshtliev, N. V. et al. FEBS Lett. 583, 1481–1488 (2009).
Song, X. et al. Int. J. Mol. Sci. 21, https://doi.org/10.3390/ijms21062122 (2020).
Acknowledgements
S.T. and C.C. and are supported by the National Institutes of Health (NIH) (grant R00-DK122019) and the American Heart Association (23IPA1054013). J.R.B. is supported by the NIH Office of the Director (DP5 OD028125) and Burroughs Wellcome Fund (CAMS 1019648).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
J.R.B. has pending and issued patents related to mitochondria transfer and obesity; has been a consultant for DeciBio and Flagship Pioneering within the past 12 months; receives royalties from Springer Nature; and is on the Scientific Advisory Board for LUCA Science.
Peer review
Peer review information
Nature Cell Biology thanks Martin Picard, Carlos Moraes and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.
Rights and permissions
About this article
Cite this article
Tiash, S., Brestoff, J.R. & Crewe, C. A guide to studying mitochondria transfer. Nat Cell Biol 25, 1551–1553 (2023). https://doi.org/10.1038/s41556-023-01246-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-023-01246-1
- Springer Nature Limited
This article is cited by
-
Horizontal mitochondrial transfer as a novel bioenergetic tool for mesenchymal stromal/stem cells: molecular mechanisms and therapeutic potential in a variety of diseases
Journal of Translational Medicine (2024)
-
Real-time study of spatio-temporal dynamics (4D) of physiological activities in alive biological specimens with different FOVs and resolutions simultaneously
Scientific Reports (2024)
-
Mitochondrial dysfunction: mechanisms and advances in therapy
Signal Transduction and Targeted Therapy (2024)