Pathways linked to the modification of RNA with N6-methyladenosine (m6A) are known to be involved in initiating and maintaining cancer. But many of the key components of these pathways remain undiscovered. The RBFOX2 protein has now been identified as an m6A reader involved in locus-specific chromatin regulation, with therapeutic implications for myeloid leukaemia.
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Russell, J., Tzelepis, K. A non-coding m6A reader promotes leukaemia. Nat Cell Biol 25, 1247–1249 (2023). https://doi.org/10.1038/s41556-023-01205-w
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DOI: https://doi.org/10.1038/s41556-023-01205-w
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