A fast protocol for chemical cellular reprogramming reveals a diapause-like state, endogenous retrovirus activation and barriers to cell-fate transitions on the way to pluripotency. The system offers insights into manipulation of cellular regeneration and rejuvenation, two processes with great therapeutic potential.
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Memczak, S., Izpisua Belmonte, J.C. Chemical fast track to induced pluripotency. Nat Cell Biol 25, 1079–1080 (2023). https://doi.org/10.1038/s41556-023-01202-z
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DOI: https://doi.org/10.1038/s41556-023-01202-z
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