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DNA replication

Transient chromatin compaction in fork restart

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The compact state of chromatin induced by the methylation of lysine 9 on histone H3 has long been implicated in a heritable state of transcriptional repression. A study now shows that transient deposition of H3K9me3 helps to stabilize stalled DNA replication forks, while its reversal enables accurate fork restart.

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Fig. 1: A replication fork challenged by hydroxyurea or other replication stress.

References

  1. Bell, O., Burton, A., Dean, C., Gasser, S. M. & Torres-Padilla, M. E. Nat. Rev. Mol. Cell Biol. https://doi.org/10.1038/s41580-023-00599-7 (2023).

    Article  PubMed  Google Scholar 

  2. Gaggioli, V. et al. Nat. Cell Biol. https://doi.org/s41556-023-01167-z (2023).

  3. Guilliam, T. A. et al. Nucleic Acids Res. 43, 1056–1068 (2015).

    Article  CAS  PubMed  Google Scholar 

  4. Dungrawala, H. & Cortez, D. Methods Mol. Biol. 1228, 123–131 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Honjoh, H. et al. Sci. Rep. 12, 17140 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Nakamura, K. et al. Nat. Cell Biol. 21, 311–318 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Witus, S. R., Stewart, M. D. & Klevit, R. E. Biochem. J. 478, 3467–3483 (2021).

    Article  PubMed  Google Scholar 

  8. Witus, S. R. et al. Nat. Struct. Mol. Biol. 28, 268–277 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Carone, D. M. & Lawrence, J. B. Semin. Cancer Biol. 23, 99–108 (2013).

    Article  CAS  PubMed  Google Scholar 

  10. Padeken, J. et al. Genes Dev. 33, 436–451 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Sulkowski, P. L. et al. Nature 582, 586–591 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ginjala, V. et al. Sci. Rep. 7, 16613 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Macheret, M. & Halazonetis, T. D. Annu. Rev. Pathol. 10, 425–448 (2015).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. ISREC Foundation, Agora Cancer Research Center, Lausanne, Switzerland

    Susan M. Gasser

  2. University of Lausanne, Department of Fundamental Microbiology, Lausanne, Switzerland

    Susan M. Gasser

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  1. Susan M. Gasser
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Correspondence to Susan M. Gasser.

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Gasser, S.M. Transient chromatin compaction in fork restart. Nat Cell Biol 25, 931–932 (2023). https://doi.org/10.1038/s41556-023-01181-1

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