Direct conversions offer an alternative approach to generate insulin-producing cells for cell therapy in diabetes. A study reports a method to convert human stomach-derived gastric stem cells into functional insulin-producing cells through a unique differentiation path.
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References
Sato, T. et al. Nature 459, 262–265 (2009).
Huang, X. G. W. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01130-y (2023).
Ariyachet, C. et al. Cell Stem Cell 18, 410–421 (2016).
Ferber, S. et al. Nat. Med. 6, 568–572 (2000).
Zhou, Q. et al. Nature 455, 627–632 (2008).
Banga, A. et al. Proc. Natl Acad. Sci. USA 109, 15336–15341 (2012).
Yoshihara, E. Front. Cell Dev. Biol. 10, 854604 (2022).
Yoshihara, E. et al. Nature 586, 606–611 (2020).
Nasteska, D. et al. Nat. Commun. 12, 4521 (2021).
Egozi, A. et al. Nat. Med. 27, 2104–2107 (2021).
Plisetskaya, E. et al. Gen. Comp. Endocrinol. 35, 133–145 (1978).
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J.C. and F.C. contributed equally to this work.
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Choi, J., Cayabyab, F. & Yoshihara, E. A guide from the stomach to β cells. Nat Cell Biol 25, 637–638 (2023). https://doi.org/10.1038/s41556-023-01140-w
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DOI: https://doi.org/10.1038/s41556-023-01140-w
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