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Phase separation

+TIPs condense on microtubule plus-ends

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End-binding proteins attach to the dynamic plus-ends of microtubules in order to regulate microtubule polymerization and the transport of other plus-end tracking proteins (+TIPs). Three new studies dissect the multivalent interactions that constitute distinct +TIP networks and reveal that they give rise to liquid-like biomolecular condensates.

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Fig. 1: Condensates of plus-end tracking proteins on microtubules.

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Authors and Affiliations

  1. Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA

    Bernardo Gouveia

  2. Department of Molecular Biology, Princeton University, Princeton, NJ, USA

    Sabine Petry

Authors
  1. Bernardo Gouveia
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  2. Sabine Petry
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Correspondence to Sabine Petry.

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The authors declare no competing interests.

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Gouveia, B., Petry, S. +TIPs condense on microtubule plus-ends. Nat Cell Biol 25, 12–14 (2023). https://doi.org/10.1038/s41556-022-01068-7

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