DNMT3A is best known for its de novo DNA methyltransferase activity. But a new study shows that the protein also has a role in RNA splicing during activation of embryonic and haematopoietic stem cells. This introduces a new perspective for approaching diseases associated with DNMT3A mutations.
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Carmo-Fonseca, M. A twist to splicing regulation in haematopoiesis. Nat Cell Biol 25, 516–517 (2023). https://doi.org/10.1038/s41556-022-01043-2
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DOI: https://doi.org/10.1038/s41556-022-01043-2
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