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Waxy lipids and waning insulin secretion

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In type 2 diabetes, altered lipid metabolism causes a defect in insulin secretion. A study now shows how reduced very long-chain sphingolipids in β cells may impair the export of insulin-processing enzymes from the endoplasmic reticulum. The resulting defect in insulin production causes increased blood glucose concentrations.

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Fig. 1: Diabetes-associated lipotoxicity in pancreatic β cells may be characterized by a selective reduction in specific VLSL species, which results in impaired processing of proinsulin to produce insulin.

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Authors and Affiliations

  1. Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA

    Jonathan S. Bogan

  2. Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA

    Jonathan S. Bogan

  3. Yale Center for Molecular and Systems Metabolism, Yale School of Medicine, New Haven, CT, USA

    Jonathan S. Bogan

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  1. Jonathan S. Bogan
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Correspondence to Jonathan S. Bogan.

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Bogan, J.S. Waxy lipids and waning insulin secretion. Nat Cell Biol 25, 7–8 (2023). https://doi.org/10.1038/s41556-022-01036-1

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