Primary cilia transduce cues, including Hedgehog (Hh) signals, and possess doublet microtubules that interact with kinesin motors. The kinesin KIF7 is important for Hh signalling and binds to GLI transcription factors. Haque et al. reveal that, surprisingly, GLI proteins bind a DNA-like part of KIF7 to promote their accumulation at the ciliary tip.
This is a preview of subscription content, log in via an institution to check access.
References
Bangs, F. & Anderson, K. V. Cold Spring Harb. Perspect. Biol. 9, a028175 (2017).
Haque, F. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00935-7 (2022).
Hui, C. C. & Angers, S. Annu. Rev. Cell Dev. Biol. 27, 513–537 (2011).
Radhakrishnan, A., Goldstein, J. L., McDonald, J. G. & Brown, M. S. Cell Metab. 8, 512–521 (2008).
Dong, C., Li, Z., Alvarez, R., Feng, X. H. & Goldschmidt-Clermont, P. J. Mol. Cell 5, 27–34 (2000).
Ziegelbauer, J. et al. Mol. Cell 8, 339–349 (2001).
He, M. et al. Nat. Cell Biol. 16, 663–672 (2014).
Santos, N. & Reiter, J. F. J. Cell Sci. 127, 1500–1510 (2014).
Liem, K. F., He, M., Ocbina, P. J. R. & Anderson, K. V. Proc. Natl Acad. Sci. USA 106, 13377–13382 (2009).
Tay, S. Y., Ingham, P. W. & Roy, S. Development 132, 625–634 (2005).
Putoux, A. et al. Nat. Genet. 43, 601–606 (2011).
Dafinger, C. et al. J. Clin. Invest. 121, 2662–2667 (2011).
Bochkareva, E. et al. Proc. Natl Acad. Sci. USA 102, 15412–15417 (2005).
Liu, D. et al. Cell 94, 573–583 (1998).
Tukachinsky, H., Lopez, L. V. & Salic, A. J. Cell Biol. 191, 415–428 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Kumar, D., Reiter, J.F. A kinesin mimics DNA. Nat Cell Biol 24, 1015–1016 (2022). https://doi.org/10.1038/s41556-022-00958-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-022-00958-0
- Springer Nature Limited