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Not all cortical organoids are created equal

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Multiple methods for deriving human cortical organoids have been established in the past decade. A study now systematically compares patterning strategies and shows that combined WNT and dual SMAD inhibition is superior to dual SMAD inhibition alone in inducing robust cortical identity in 3D human pluripotent stem-cell aggregates.

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Fig. 1: Dissecting in vivo developmental cues to improve modelling of human development and disease.

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Authors and Affiliations

  1. Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Alexander Atamian, Marcella Birtele & Giorgia Quadrato

  2. Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at the University of Southern California, Los Angeles, CA, USA

    Alexander Atamian, Marcella Birtele & Giorgia Quadrato

Authors
  1. Alexander Atamian
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  2. Marcella Birtele
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  3. Giorgia Quadrato
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Correspondence to Giorgia Quadrato.

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The authors declare no competing interests.

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Atamian, A., Birtele, M. & Quadrato, G. Not all cortical organoids are created equal. Nat Cell Biol 24, 805–806 (2022). https://doi.org/10.1038/s41556-022-00890-3

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