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Mitochondrial shape alteration by metabolites

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Organic acidurias are inherited disorders that can severely affect mitochondria. A study in Caenorhabditis elegans suggests that binding of a toxic metabolite to a factor crucial for mitochondrial structure may contribute to disease mechanisms.

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Fig. 1: Mitochondrial damage by dysfunction of a propionyl-CoA degradation pathway.

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Authors and Affiliations

  1. Institute of Cell Biology, University of Bayreuth, Bayreuth, Germany

    Till Klecker & Benedikt Westermann

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  1. Till Klecker
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  2. Benedikt Westermann
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Correspondence to Benedikt Westermann.

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The authors declare no competing interests.

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Klecker, T., Westermann, B. Mitochondrial shape alteration by metabolites. Nat Cell Biol 24, 410–412 (2022). https://doi.org/10.1038/s41556-022-00889-w

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