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Phosphoinositide phosphorylation sans kinase

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Phosphoinositide signalling regulates cellular processes and is hijacked by pathogens. Classically, phosphoinositides are produced by kinase- and phosphatase-catalysed reactions. A study now reveals an unprecedented, kinase- and ATP-free synthesis of PtdIns(3,4)P2 via a phosphotransferase mechanism during bacterial infection.

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Fig. 1: Kinase- and ATP-independent PtdIns(3,4)P2 generation from PtdIns(4,5)P2 by the bacterial effector SopB.

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Authors and Affiliations

  1. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA

    Xiaofu Cao & Jeremy M. Baskin

  2. Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA

    Xiaofu Cao & Jeremy M. Baskin

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  1. Xiaofu Cao
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  2. Jeremy M. Baskin
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Correspondence to Jeremy M. Baskin.

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Cao, X., Baskin, J.M. Phosphoinositide phosphorylation sans kinase. Nat Cell Biol 24, 604–606 (2022). https://doi.org/10.1038/s41556-022-00885-0

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