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Selective tRNA charging in breast cancer

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Increased tRNA abundance and amino acid coupling generally promote increased oncogenesis. By contrast, a new study shows that in breast cancer, the leucyl-tRNA synthetase LARS suppresses transformation and tumour development by increasing tRNA-LeuCAG translation of certain tumour suppressor mRNAs.

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Fig. 1: Downregulation of aminoacyl-tRNA synthetase LARS in breast cancer promotes transformation.

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Authors and Affiliations

  1. Department of Microbiology, NYU Grossman School of Medicine, New York, NY, USA

    C. Theresa Vincent & Robert J. Schneider

  2. Department of Immunology, Genetics and Pathology (IGP), Uppsala University, Uppsala, Sweden

    C. Theresa Vincent

Authors
  1. C. Theresa Vincent
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  2. Robert J. Schneider
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Correspondence to Robert J. Schneider.

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Vincent, C.T., Schneider, R.J. Selective tRNA charging in breast cancer. Nat Cell Biol 24, 287–289 (2022). https://doi.org/10.1038/s41556-022-00863-6

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