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Chaperone-mediated autophagy on the clock

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Rhythmic removal of circadian clock proteins is important for the strength and periodicity of the circadian rhythm. A study now reveals that chaperone-mediated autophagy regulates the degradation of circadian proteins, and is also transcriptionally regulated by the circadian machinery. This feedback loop helps to maintain circadian oscillations.

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Fig. 1: A reciprocal negative-feedback loop ensures rhythmic oscillations of CMA activity and circadian protein levels in daily clock cycles.

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    Congcong He

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  1. Congcong He
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Correspondence to Congcong He.

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He, C. Chaperone-mediated autophagy on the clock. Nat Cell Biol 23, 1220–1221 (2021). https://doi.org/10.1038/s41556-021-00811-w

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