The collapse of DNA replication forks leads to the formation of single-ended DNA double-strand breaks. One would have assumed that these breaks would be repaired as soon as possible. However, a recent study suggests that a delay in DNA polymerase θ-mediated end joining until mitosis, orchestrated by BRCA2 and RAD52, favors genomic stability.
References
Macheret, M. & Halazonetis, T. D. Annu. Rev. Pathol. Mech. Dis. 10, 425–448 (2015).
Schumacher, B., Pothof, J., Vijg, J. & Hoeijmakers, J. H. J. Nature 592, 695–703 (2021).
Branzei, D. & Foiani, M. Nat. Rev. Mol. Cell Biol. 11, 208–219 (2010).
Scully, R., Panday, A., Elango, R. & Willis, N. A. Nat. Rev. Mol. Cell Biol. 20, 698–714 (2019).
Llorens-Agost, et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00764-0 (2021).
Giannattasio, M. et al. Nat. Struct. Mol. Biol. 21, 884–892 (2014).
Schlacher, K. et al. Cell 145, 529–542 (2011).
Sotiriou, S. K. et al. Mol. Cell 64, 1127–1134 (2016).
Bhowmick, R., Minocherhomji, S. & Hickson, I. D. Mol. Cell 64, 1117–1126 (2016).
Kockler, Z. W., Osia, B., Lee, R., Musmaker, K. & Malkova, A. Annu. Rev. Biochem. 90, 165–191 (2021).
Sfeir, A. & Symington, L. S. Trends Biochem. Sci. 40, 701–714 (2015).
Wang, Z. et al. J. Biol. Chem. 294, 3909–3919 (2019).
Smith, C. E., Llorente, B. & Symington, L. S. Nature 447, 102–105 (2007).
Feng, Z. et al. Proc. Natl. Acad. Sci. USA 108, 686–691 (2011).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Petropoulos, M., Halazonetis, T.D. Delayed DNA break repair for genome stability. Nat Cell Biol 23, 1055–1057 (2021). https://doi.org/10.1038/s41556-021-00769-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41556-021-00769-9
- Springer Nature Limited