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Eosinophils set DNA traps in allergic asthma

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The underlying molecular and cellular mechanisms for asthma remain incompletely understood. A new study now shows that eosinophils release DNA traps that stimulate pulmonary neuroendocrine cell-mediated amplification of the allergic asthma response.

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Fig. 1: Allergen EET release by eosinophils reinforces PNEC-mediated type 2 immunity.

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Authors and Affiliations

  1. Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA

    Barsha Dash & Xin Sun

  2. Division of Biological Sciences, University of California at San Diego, La Jolla, CA, USA

    Xin Sun

Authors
  1. Barsha Dash
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  2. Xin Sun
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Correspondence to Xin Sun.

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The authors declare no competing interests.

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Dash, B., Sun, X. Eosinophils set DNA traps in allergic asthma. Nat Cell Biol 23, 1057–1059 (2021). https://doi.org/10.1038/s41556-021-00765-z

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