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EZH2 accompanies prostate cancer progression

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Enhancer of zeste homolog 2 (EZH2) has been shown to promote development of castration-resistant prostate cancer (CRPC) through various mechanisms. A new study now shows that a phosphorylated EZH2 interacts with the androgen receptor (AR) and reprograms AR transcriptional activity to facilitate transition of CRPC into a lineage infidelity state.

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Fig. 1: EZH2 plays a multifaceted role in prostate cancer progression.

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Authors and Affiliations

  1. Department of Urology, University of Washington, Seattle, WA, USA

    Li Xin

  2. Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA

    Li Xin

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  1. Li Xin
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Correspondence to Li Xin.

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The authors declare no competing interests.

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Xin, L. EZH2 accompanies prostate cancer progression. Nat Cell Biol 23, 934–936 (2021). https://doi.org/10.1038/s41556-021-00744-4

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