Many endocytic uptake events depend on the ‘pinchase’ activity of dynamin. By measuring the orientation of single gold nanorods, a new study reveals that invaginated clathrin-coated endocytic pits undergo a strong rotational twist prior to or concomitant with their detachment.
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References
Kaksonen, M. & Roux, A. Nat. Rev. Mol. Cell Biol. 19, 313–326 (2018).
Johannes, L., Parton, R. G., Bassereau, P. & Mayor, S. Nat. Rev. Mol. Cell Biol. 16, 311–321 (2015).
Renard, H.-F., Johannes, L. & Morsomme, P. Trends Cell Biol. 28, 274–286 (2018).
Antonny, B. et al. EMBO J. 35, 2270–2284 (2016).
Schmid, S. L. & Frolov, V. A. Annu. Rev. Cell Dev. Biol. 27, 79–105 (2011).
Roux, A., Uyhazi, K., Frost, A. & De Camilli, P. Nature 441, 528–531 (2006).
Colom, A., Redondo-Morata, L., Chiaruttini, N., Roux, A. & Scheuring, S. Proc. Natl Acad. Sci. USA 114, 5449–5454 (2017).
Cheng, X. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00713-x (2021).
Curcio, V., Alemán-Castañeda, L. A., Brown, T. G., Brasselet, S. & Alonso, M. A. Nat. Commun. 11, 5307 (2020).
Zhang, O., Lu, J., Ding, T. & Lew, M. D. Appl. Phys. Lett. 113, 031103 (2018).
Valades Cruz, C. A. et al. Proc. Natl Acad. Sci. USA 113, E820–E828 (2016).
Mehta, S. B. et al. Proc. Natl Acad. Sci. USA 113, E6352–E6361 (2016).
van der Bliek, A. M. et al. J. Cell Biol. 122, 553–563 (1993).
Jimah, J. R. & Hinshaw, J. E. Trends Cell Biol. 29, 257–273 (2019).
Balla, N. K. et al. ACS Photonics 4, 292–301 (2017).
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Johannes, L., Valades-Cruz, C.A. The final twist in endocytic membrane scission. Nat Cell Biol 23, 812–813 (2021). https://doi.org/10.1038/s41556-021-00711-z
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DOI: https://doi.org/10.1038/s41556-021-00711-z
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