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PHF7 directs cardiac reprogramming

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Epigenetic barriers need to be surmounted in order to increase the efficiency of cardiac reprogramming. A new study now reports that the histone reader PHF7 enhances cardiac reprogramming via recruiting the chromatin remodelling SWI/SNF complex and key transcription factors to the cardiac super enhancers.

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Fig. 1: Histone code reader PHF7 is a precision epigenetic regulator that increases cardiac reprogramming efficiency.

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Authors and Affiliations

  1. Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden

    Elif Eroglu, John P. Schell & Kenneth R. Chien

Authors
  1. Elif Eroglu
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  2. John P. Schell
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  3. Kenneth R. Chien
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Correspondence to Kenneth R. Chien.

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The authors declare no competing interests.

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Eroglu, E., Schell, J.P. & Chien, K.R. PHF7 directs cardiac reprogramming. Nat Cell Biol 23, 440–442 (2021). https://doi.org/10.1038/s41556-021-00684-z

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