Skip to main content
SpringerLink
Log in

GENOME STABILITY

MSL pushes genomic instability over the edge

  • News & Views
  • Published:

From Nature Cell Biology

View current issue Submit your manuscript

Chromosomal instability (CIN) is a hallmark of malignant evolution that underpins cancer progression and therapeutic evasion. There are few established experimental systems to study CIN and ultimately develop potential therapeutic options. A new study now identifies the MSL chromatin complex as a potential vulnerability against CIN in cancer cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Role of the MSL complex in tumour cell maintenance.

References

  1. McDonald 3rd, E. R. et al. Cell 170, 577–592.e10 (2017).

    Article  CAS  Google Scholar 

  2. Tsherniak, A. et al. Cell 170, 564–576.e16 (2017).

    Article  CAS  Google Scholar 

  3. Josep, M. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-021-00657-2 (2021).

  4. Negrini, S., Gorgoulis, V. G. & Halazonetis, T. D. Nat. Rev. Mol. Cell Biol. 11, 220–228 (2010).

    Article  CAS  Google Scholar 

  5. Sheikh, B. N. & Akhtar, A. Nat. Rev. Genet. 20, 7–23 (2019).

    Article  CAS  Google Scholar 

  6. Scaffidi, P. & Misteli, T. Nat. Cell Biol. 13, 1051–1061 (2011).

    Article  CAS  Google Scholar 

  7. Ben-David, U. & Amon, A. Nat. Rev. Genet. 21, 44–62 (2020).

    Article  CAS  Google Scholar 

  8. Shogren-Knaak, M. et al. Science 311, 844–847 (2006).

    Article  CAS  Google Scholar 

  9. Groth, A., Rocha, W., Verreault, A. & Almouzni, G. Cell 128, 721–733 (2007).

    Article  CAS  Google Scholar 

  10. Clemente-Ruiz, M. et al. Dev. Cell 36, 290–302 (2016).

    Article  CAS  Google Scholar 

  11. Baell, J. B. et al. Nature 560, 253–257 (2018).

    Article  CAS  Google Scholar 

  12. MacPherson, L. et al. Nature 577, 266–270 (2020).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

    Ali Motazedian & Mark A. Dawson

  2. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia

    Ali Motazedian & Mark A. Dawson

  3. The University of Melbourne Centre for Cancer Research, The University of Melbourne, Melbourne, Victoria, Australia

    Mark A. Dawson

Authors
  1. Ali Motazedian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mark A. Dawson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark A. Dawson.

Ethics declarations

Competing interests

M.A.D. has been a member of advisory boards for GlaxoSmithKline, CTX CRC, Storm Therapeutics, Celgene and Cambridge Epigenetix. The M.A.D. laboratory received research funding from CTx CRC.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Motazedian, A., Dawson, M.A. MSL pushes genomic instability over the edge. Nat Cell Biol 23, 295–296 (2021). https://doi.org/10.1038/s41556-021-00666-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-021-00666-1

  • Springer Nature Limited

Search

Navigation