Ferroptosis is an iron-dependent mode of cell death driven by lipid peroxidation, capable of explosively propagating through a field of cells. Two studies now explore the mechanisms underlying ferroptotic cell death and its spread, as well as its possible in vivo significance, shedding light on some of the burning questions surrounding ferroptosis.
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Davidson, A.J., Wood, W. Igniting the spread of ferroptotic cell death. Nat Cell Biol 22, 1027–1029 (2020). https://doi.org/10.1038/s41556-020-0570-4
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DOI: https://doi.org/10.1038/s41556-020-0570-4
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