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Bridging naïve and primed pluripotency

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Pluripotent cells generate all types of cells in the body and have largely been classified dichotomously into two types: naïve and primed. Arguing against a binary classification system, a study now discovers a unique transition state between naïve and primed pluripotency and describes the signals that control this transition.

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Fig. 1: A continuum of pluripotent states in the early mouse embryo.

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Authors and Affiliations

  1. Department of Developmental Biology, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA

    Carolyn E. Dundes & Kyle M. Loh

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  1. Carolyn E. Dundes
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  2. Kyle M. Loh
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Correspondence to Kyle M. Loh.

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The authors declare no competing interests.

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Dundes, C.E., Loh, K.M. Bridging naïve and primed pluripotency. Nat Cell Biol 22, 513–515 (2020). https://doi.org/10.1038/s41556-020-0509-9

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