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Optimising gene editing for cancer therapy

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Gene editing holds promise for the treatment of cancers that are driven by well-characterised molecular alterations. A study now provides a proof of concept for the feasibility of in vivo gene editing to correct TERT mutations in glioblastoma, providing a platform for the direct manipulation of genetic alterations to reduce tumour growth.

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Fig. 1: TERT promoter activity in glioblastoma tumour cells.

References

  1. Doudna, J. A. & Charpentier, E. Science 346, 1258096 (2014).

    Article  Google Scholar 

  2. Li, X. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-020-0471-6 (2020).

  3. Ostrom, Q. T. et al. Neuro-oncol. 21, v1–v100 (2019).

    Article  Google Scholar 

  4. Killela, P. J. et al. Proc. Natl Acad. Sci. USA 110, 6021–6026 (2013).

    Article  CAS  Google Scholar 

  5. Walsh, K. M. et al. Nat. Genet. 46, 731–735 (2014).

    Article  CAS  Google Scholar 

  6. Blackburn, E. H. Nature 350, 569–573 (1991).

    Article  CAS  Google Scholar 

  7. Campisi, J., Kim, S. H., Lim, C. S. & Rubio, M. Exp. Gerontol. 36, 1619–1637 (2001).

    Article  CAS  Google Scholar 

  8. Horn, S. et al. Science 339, 959–961 (2013).

    Article  CAS  Google Scholar 

  9. Bell, R. J. A. et al. Science 348, 1036–1039 (2015).

    Article  CAS  Google Scholar 

  10. Tan, J., Zhang, F., Karcher, D. & Bock, R. Nat. Commun. 10, 1 (2019).

    Article  Google Scholar 

  11. Mancini, A. et al. Cancer Cell 34, 513–528.e8 (2018).

    Article  CAS  Google Scholar 

  12. Jeong, D. E. et al. Oncol. Lett. 14, 8213–8219 (2017).

    PubMed  PubMed Central  Google Scholar 

  13. Alexandrov, L. B. et al. Nature 578, 94–101 (2020).

    Article  Google Scholar 

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Authors and Affiliations

  1. Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA

    Katie Troike & Justin D. Lathia

  2. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA

    Katie Troike & Justin D. Lathia

  3. Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA

    Justin D. Lathia

  4. Case Comprehensive Cancer Center, Cleveland, OH, USA

    Justin D. Lathia

Authors
  1. Katie Troike
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  2. Justin D. Lathia
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Correspondence to Justin D. Lathia.

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The authors declare no competing interests.

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Troike, K., Lathia, J.D. Optimising gene editing for cancer therapy. Nat Cell Biol 22, 259–261 (2020). https://doi.org/10.1038/s41556-020-0480-5

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